Thursday 16 January 2014

The EPO Gene: Enhancing, Altering, Re-Balancing, Cheating.....?


There was some interesting news recently reported by the BBC about the potential of athletes, and in particular cyclists, to implant a gene which helps the body manufacture additional amounts of the hormone erythpoietin. It is more widely known as EPO.

 


EPO was used illicitly by cyclists such as Marco Pantani and Lance Armstrong and causes increased levels of red blood cells in the body, enabling more oxygen to get to the muscle groups and in turn allowing an individual to have great strength and endurance. Perfect ingredients for a professional cyclist.

 

Gene therapy involves planting genes into the body and is currently being investigated by scientists for its use in battling debilitating diseases such as haemophilia and conditions such as blindness - the medical journal  Lancet recently reported the partially regained sight of 6 patients whose eyes had been injected with a gene which they had formerly been missing.

 

But as the report makes clear, this research has also attracted the interests of former Tour cyclists - the inference being that cyclists will be at an advantage if their body is seen to be producing additional amounts of EPO naturally through their genes, rather than artificially introduced into their blood.  The French scientist, Philippe Moullier, who had been approached by the cyclists, related how they then seemed relatively cavalier about the possibility of harmful side effects e.g. thickening of the blood and clots which are associated with the abnormal production of red blood cells. The implication being that the competition in the world of cycling was so fierce, the will to win so intense, that riders were willing to take the ultimate risk to achieve in their chosen sport.

 

The fact that these genes were available simply at the end of a Google search and purchase was a further level of concern. So too the possibility that the gene directly injected into the muscle could disappear and leave no trace within days.


Predictably, WADA (World Anti Doping Association) was both aware of gene doping and has detection strategies in place, but for obvious reasons was not keen to cast light on the  nature of these strategies.

 

For the outside interested observer it once again raises questions about how level the field is when watching sports. Going deeper it raises questions about what a level playing field is in the first place. Who's to deny an athlete with a naturally low red blood count from making use of a gene to boost his level to equal those of other competitors? If an EPO gene is being used generally in the future to make muscles last longer and be more effective in life, what's to stop a sportsperson from extending their sporting career by using it?

 

And where in the world of professional sport the differences between glorious victory and an ephemeral second place are mili seconds, what's the role of science in general as regards performance? Power meters, heart rate thresholds, dietary information, cycle aerodynamics and design, VO2 max are all products of a science which helps the sports person ultimately perform better. Are these therefore not to be made available to the sportsperson?

 

Like the use of the EPO gene, these are questions which beg more questions and where black and white dissolve to an opaque grey.

 

To read the article:


 

To listen to the BBC report:

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